When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

Metastasis may arise years after removal of a primary tumor. The mechanisms allowing
latent disseminated cancer cells to survive are unknown. We report that a gene expression …

Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors,
HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐and metastasis‐initiating …

The importance of cancer stem cells (CSCs) in tumor-initiation has been firmly established in
leukemia and recently reported for a variety of solid tumors. However, the role of CSCs in …

The chemokine CXCL12 (SDF-1) and its cell surface receptor CXCR4 were first identified as
regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 …

The incidence and mortality rates of prostate cancer are significantly higher in African-
American men when compared with European-American men. We tested the hypothesis that …

In industrialized countries, cancer is the second leading cause of death after cardiovascular
disease. Most cancer patients die because of metastases, which consist of the self …