Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Inflammatory response can be driven by cytokine production and is a pivotal target in the
management of inflammatory diseases. Monoterpenes have shown that promising profile as …

Cyclodextrins (CDs) are cyclic oligosaccharides can enhance the bioavailability of drugs.
Ocimum basilicum is an aromatic plant found in Brazil used in culinary. The essential oil of …

Directed transformation of available natural compounds with native biological activity is a
promising area of research in organic and medicinal chemistry aimed at finding effective …

Annona vepretorum is an endemic species of the Caatinga biome, known in Northeastern
Brazil as" araticum” and/or “pinha da Caatinga”. In the present study it was evaluated the …

The anti-hyperalgesic effect of the complex containing α-terpineol (αTPN) and β-cyclodextrin
(βCD) was analyzed in a non-inflammatory chronic muscle pain model, as well as its …

Chronic musculoskeletal pain is one of the main symptoms found in Fibromyalgia with
unclear etiology and limited pharmacological treatment. The aim of this study was to …

Background Citronellal (CT) is a monoterpene with antinociceptive acute effect. β-
Cyclodextrin (βCD) has enhanced the analgesic effect of various substances …

Complexation with cyclodextrins (CDs) is a technique that has been extensively used to
increase the aqueous solubility of oils and improve their stability. In addition, this technique …

Geraniol (GER) is a monoterpene alcohol with various biochemical and pharmacological
properties present in the essential oil of more than 160 species of herbs (especially the …