[HTML][HTML] Animal models of osteoarthritis: classification, update, and measurement of outcomes
EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …
[HTML][HTML] Osteoarthritis associated with estrogen deficiency
JA Roman-Blas, S Castañeda, R Largo… - Arthritis research & …, 2009 - Springer
Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although
articular tissues have long been considered unresponsive to estrogens or their deficiency …
articular tissues have long been considered unresponsive to estrogens or their deficiency …
[HTML][HTML] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
VB Kraus, B Burnett, J Coindreau, S Cottrell… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …
biomarkers may be able to provide a more rapid indication of therapeutic responses to …
[HTML][HTML] Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future
MA Karsdal, M Michaelis, C Ladel, AS Siebuhr… - Osteoarthritis and …, 2016 - Elsevier
Osteoarthritis (OA) is the biggest unmet medical need among the many musculoskeletal
conditions and the most common form of arthritis. It is a major cause of disability and …
conditions and the most common form of arthritis. It is a major cause of disability and …
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
[HTML][HTML] Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
M Bellido, L Lugo, JA Roman-Blas, S Castañeda… - Arthritis research & …, 2010 - Springer
Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …
[HTML][HTML] Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain (LBP) is the world's leading cause of disability and is increasing in
prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) …
prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) …
[HTML][HTML] Should subchondral bone turnover be targeted when treating osteoarthritis?
OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritic disease, and it is a
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …
Estrogens, osteoarthritis and inflammation
M Martín-Millán, S Castañeda - Joint Bone Spine, 2013 - Elsevier
Estrogens participate in several biological processes through different molecular
mechanisms. Their final actions consist of a combination of both direct and indirect effects on …
mechanisms. Their final actions consist of a combination of both direct and indirect effects on …
[HTML][HTML] Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment–a systematic approach
YH Sniekers, H Weinans, SM Bierma-Zeinstra… - Osteoarthritis and …, 2008 - Elsevier
OBJECTIVE: The prevalence of osteoarthritis (OA) increases dramatically in women after the
age of 50. Animal models are used to study the effects of hormone depletion [by ovariectomy …
age of 50. Animal models are used to study the effects of hormone depletion [by ovariectomy …