DNA-encoded chemical libraries (DELs) have emerged as a powerful technology in drug
discovery. The wide adoption of DELs in the pharmaceutical industry and the rapid …

DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …

Several combinatorial methods have been developed to create focused or diverse chemical
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …

In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …

The discovery of organic ligands that bind specifically to proteins is a central problem in
chemistry, biology, and the biomedical sciences. The encoding of individual organic …

The world is totally dependent on medications. As science progresses, new, better, and
cheaper drugs are needed more than ever. The pharmaceutical industry has been …

Terminal deoxynucleotidyl transferase (TdT) is an unusual DNA polymerase that adds
untemplated dNTPs to 3′-ends of DNA. If a target protein is expressed as a TdT fusion and …

Conventional cancer chemotherapy heavily relies on the use of cytotoxic agents, which
typically do not preferentially localize at the tumor site and cause toxicity to normal organs …

In nature, specific antibodies can be generated as a result of an adaptive selection and
expansion of lymphocytes with suitable protein binding properties. We attempted to mimic …

Using (hetero) aryl fluorosulfonates as versatile electrophiles, facile on‐DNA cross‐coupling
reactions of Suzuki, Sonogashira, and Buchwald are reported here. Notably, all of these …