The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS-and autophagy-
dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been …

Replicative crisis is a senescence-independent process that acts as a final barrier against
oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle …

Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

Background & Aims Autophagy plays a crucial role in hepatic homeostasis and its
deregulation has been associated with chronic liver disease. However, the effect of …

Although the transition metal copper (Cu) is an essential nutrient that is conventionally
viewed as a static cofactor within enzyme active sites, a non-traditional role for Cu as a …

Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …