Engineered nano–bio interfaces–driven by vertical micro/nanoneedles, nanoparticles, organ‐
on‐chip devices, and a diversity of nanosubstrates for mass spectroscopy imaging–are …

Despite achieving optimal initial responses to androgen deprivation therapy, most patients
with prostate cancer eventually progress to a poor prognosis state known as castration …

Abstract The Androgen Receptor (AR) is a ligand (androgen) activated transcription factor
and a member of the nuclear receptor (NR) superfamily. It is required for male sex hormone …

Background Bone is the most common site of metastasis of prostate cancer (PCa). PCa
invasion leads to a disruption of osteogenic-osteolytic balance and causes abnormal bone …

Abstract Background Prostate cancer (PCa) is the most frequently diagnosed non-skin
cancer and a leading cause of mortality among males in developed countries. However, our …

Prostate cancer (PCa) remains a leading cause of mortality among American men, with
metastatic and recurrent disease posing significant therapeutic challenges due to a limited …

Statins comprise a class of prescription drugs used for reducing cholesterol. Evidence has
also showed that statins could reduce cancer incidence. However, the anti-tumor …

High mass resolution mass spectrometry provides hundreds to thousands of protein
identifications per sample, and quantification is typically performed using label-free …

Introduction Prostate cancer (PCa) is one of the most common malignancies, and almost all
patients with advanced PCa will develop castration-resistant prostate cancer (CRPC) after …

Mass spectrometry (MS)-based proteomics is becoming a widely used technique for
proteome characterization. Remarkable improvements in the resolution and sensitivity of MS …