Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Oligomerization of membrane proteins in response to lipid binding has a critical role in many
cell-signalling pathways but is often difficult to define or predict. Here we report the …

Mass spectrometry (MS) of intact soluble protein complexes has emerged as a powerful
technique to study the stoichiometry, structure-function and dynamics of protein assemblies …

Mass spectrometry-based methods have become increasingly important in structural biology—
in particular for large and dynamic, even heterogeneous assemblies of biomolecules. Native …

Recent advances in mass spectrometry approaches to the analysis of lipids include the
ability to incorporate both lipid class identification with lipid structural information for …

Ion mobility coupled to mass spectrometry has been an important tool in the fields of
chemical physics and analytical chemistry for decades, but its potential for interrogating the …

The initial stages of drug discovery are increasingly reliant on development and
improvement of analytical methods to investigate protein–protein and protein–ligand …

Rapid advances in structural genomics and in large-scale proteomic projects have yielded
vast amounts of data on soluble proteins and their complexes. Despite these advances …

Cellular membranes comprise hundreds of lipids in which protein complexes, such as ion
channels, receptors, and scaffolding complexes, are embedded. These protein assemblies …