Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …

Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in
mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed …

The existing literature points towards the presence of robust mitochondrial mechanisms
aimed at mitigating protein dyshomeostasis within the organelle. However, the precise …

Overexpression of SNCA has been implicated in the pathogenesis of synucleinopathies,
particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While PD and …

Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …

The aberrant aggregation of α-Synuclein (αS), a disordered protein primarily localised at the
neuronal synapses, is associated with a number of neurodegenerative disorders including …

Pro-inflammatory cytokines are emerging as neuroinflammatory mediators in Parkinson's
disease (PD) due to their ability to act through neuronal cytokine receptors. Critical …

Multiple studies describe prodromal, nonmotor dysfunctions that affect the quality of life of
patients who subsequently develop Parkinson's disease (PD). These prodromal …

Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial
targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery …

Neurological disorders are the leading cause of cognitive and physical disability worldwide,
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …