Insulin-degrading enzyme (IDE) is a multifunctional protease due to the variety of its
substrates, its various cellular locations, its conservation between species and its many non …

The insulin-degrading enzyme (IDE) is a Zn2+ peptidase originally discovered as the main
enzyme involved in the degradation of insulin and other amyloidogenic peptides, such as …

More than seven decades have passed since the discovery of a proteolytic activity within
crude tissue extracts that would become known as insulin-degrading enzyme (IDE) …

Insulin-degrading enzyme (IDE) is a highly conserved zinc metallopeptidase and is capable
to catalytically cleave several substrates besides insulin, playing a pivotal role in several …

Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates
among which amyloid-β and insulin. It has been linked through genetic studies to the risk of …

Fragment-based drug discovery (FBDD) is a powerful approach for identifying molecules
that inhibit therapeutically relevant targets, focusing on the elaboration of fragment'hits' into …

Carcinogenesis cannot be explained only by genetic alterations. Epigenetic processes such
as histone modification via (de) acetylation play a key role in gene expression, where …

Amylin, also known as islet amyloid polypeptide (IAPP), is a metabolic homeostasis-related
hormone that is produced and released by the β cells of the pancreas, the same cells that …