Receptor tyrosine kinase signaling and targeting in glioblastoma multiforme

M Tilak, J Holborn, LA New, J Lalonde… - International Journal of …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

Mechanisms of Invasion in Glioblastoma: Extracellular Matrix, Ca2+ Signaling, and Glutamate

JS So, H Kim, KS Han - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common and malignant form of primary brain tumor with a
median survival time of 14–16 months in GBM patients. Surgical treatment with …

Too much of a good thing: The case of SOCE in cellular apoptosis

JC Benson, M Trebak - Cell calcium, 2023 - Elsevier
Abstract Intracellular calcium (Ca 2+) is an essential second messenger in eukaryotic cells
regulating numerous cellular functions such as contraction, secretion, immunity, growth, and …

Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α‐stimulated astrocytes

H Nakajima, S Fujita, M Kakae, K Nagayasu… - Glia, 2022 - Wiley Online Library
Astrocytes are glial cells that serve homeostatic functions in the central nervous system
(CNS). Recent research, however, suggests that under pathological conditions, astrocytes …

[HTML][HTML] Orai2 deficiency attenutates experimental colitis by facilitating the colonization of Akkermansia muciniphila

J Yan, W Yu, C Lu, G Wang, C Liu, L Jiang, Z Jiang… - Genomics, 2022 - Elsevier
Orai2 is a component of store-operated Calcium channels (SOCCs) and exerts a pivotal role
in immunity. In intestinal macrophages (Mφs), Orai2 deficiency influenced linoleic acid (LA) …

A prognostic risk model for ovarian cancer based on gene expression profiles from gene expression omnibus database

W Fan, X Chen, R Li, R Zheng, Y Wang, Y Guo - Biochemical Genetics, 2023 - Springer
This study explored prognostic genes of ovarian cancer and built a prognostic model based
on these genes to predict patient's survival, which is of great significance for improving …

A novel immune classification for predicting immunotherapy responsiveness in patients with adamantinomatous craniopharyngioma

F Yuan, X Cai, J Zhu, L Yuan, Y Wang, C Tang… - Frontiers in …, 2021 - frontiersin.org
Adamantinomatous craniopharyngioma (ACP) is the most common tumor of the sellar region
in children. The aggressive behavior of ACP challenges the treatment for it. However …

mRNA markers for survival prediction in glioblastoma multiforme patients: a systematic review with bioinformatic analyses

P Azimi, T Yazdanian, A Ahmadiani - BMC cancer, 2024 - Springer
Background Glioblastoma multiforme (GBM) is a type of fast-growing brain glioma
associated with a very poor prognosis. This study aims to identify key genes whose …

Analysis of Long Noncoding RNA ZNF667‐AS1 as a Potential Biomarker for Diagnosis and Prognosis of Glioma Patients

Q Yuan, C Gao, X Lai, L Chen, T Lai - Disease Markers, 2020 - Wiley Online Library
Objective. Long noncoding RNAs (lncRNAs) have been strongly associated with various
types of cancer. The present study aimed at exploring the diagnostic and prognostic value of …

[HTML][HTML] Featuring how calcium channels and calmodulin affect glioblastoma behavior. A review article

MA Azab, A Alomari, AY Azzam - Cancer Treatment and Research …, 2020 - Elsevier
Glioblastoma (GBM) is considered to be the most aggressive primary brain tumor with an
extremely bad prognosis. Recurrence after treatment is a major problem with a survival rate …