Leukemia often initiates following dysfunctions in hematopoietic stem cells lineages. Various
types of leukemia, including acute lymphoblastic leukemia (ALL), chronic myelogenous …

Acute Lymphoblastic Leukemia | New England Journal of Medicine Skip to main content Access
provided by Charite - Universitaetsmedizin Berlin The New England Journal of Medicine …

Cancer is characterized by unrestrained proliferation and loss of organization, a process that
is intimately linked to, and controlled by, reciprocal signaling between the genetically altered …

We performed a multi-institutional retrospective analysis of the morphologic features,
immunophenotype, cytogenetics, and BCR-ABL transcript characterization of cases of …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

Abstract The oncogenic protein Bcr-Abl has two major isoforms, p190Bcr-Abl and p210Bcr-
Abl. While p210Bcr-Abl is the hallmark of chronic myeloid leukemia (CML), p190Bcr-Abl …

Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct
the phasing analysis of non-small cell lung cancer specimens of 20 Japanese patients. By …

Chromosomal rearrangements involving the ABL1 gene, leading to a BCR‐ABL1 fusion
gene, have been mainly associated with chronic myeloid leukemia and B‐cell acute …

Purpose To identify gene expression patterns and interaction networks related to BCR-ABL
status and clinical outcome in adults with acute lymphoblastic leukemia (ALL). Patients and …

Recent advances in genetic engineering have enabled the delivery of clinical trials using
patient T cells redirected to recognize tumor-associated antigens. The most dramatic results …