Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several
antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect of
many commonly used chemotherapeutic agents, including platinum drugs, taxanes …

Fatigue is one of the most prevalent and distressing symptoms of cancer, and is a common
side-effect of many of the treatments available for the management of malignant disease. We …

Peripheral neuropathy induced by cancer chemotherapy represents a large unmet need for
patients due to the absence of treatment that can prevent or mitigate this common clinical …

Neurotoxic side effects of chemotherapy occur frequently and are often a reason to limit the
dose of chemotherapy. Since bone marrow toxicity, as the major limiting factor in most …

Microtubule-stabilizing agents (MTSAs), including the taxanes and epothilones, are effective
chemotherapeutic agents for the treatment of many cancers. Neuropathy is a major adverse …

The last decade witnessed the introduction of exciting new chemotherapeutic agents.
Among these, paclitaxel emerged as one of the most powerful compounds. Paclitaxel …

Paclitaxel is an antineoplastic agent derived from the bark of the western yew, Taxus
brevifolia, with a broad spectrum of activity. Because paclitaxel promotes microtubule …

Purpose The characteristics and natural history of the paclitaxel–acute pain syndrome (P-
APS) and paclitaxel's more chronic neuropathy have not been well delineated. Methods …

Chemotherapy-induced neurotoxicity is a significant complication in the successful treatment
of many cancers. Neurotoxicity may develop as a consequence of treatment with platinum …