How neutrophils shape the immune response: reassessing their multifaceted role in health and disease
Neutrophils are the most abundant of the circulating immune cells and are the first to be
recruited to sites of inflammation. Neutrophils are a heterogeneous group of immune cells …
recruited to sites of inflammation. Neutrophils are a heterogeneous group of immune cells …
Translating insights into therapies for Long Covid
AAR Antar, AL Cox - Science Translational Medicine, 2024 - science.org
Long Covid is defined by a wide range of symptoms that persist after the acute phase of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …
Enhanced complement activation and MAC formation accelerates severe COVID-19
CR Ellsworth, Z Chen, MT Xiao, C Qian… - Cellular and Molecular …, 2024 - Springer
Emerging evidence indicates that activation of complement system leading to the formation
of the membrane attack complex (MAC) plays a detrimental role in COVID-19. However …
of the membrane attack complex (MAC) plays a detrimental role in COVID-19. However …
Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production
Abstract Toll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated
with reduced production of interferons (IFNs). However, the underlying mechanisms remain …
with reduced production of interferons (IFNs). However, the underlying mechanisms remain …
Emerging role of complement in COVID-19 and other respiratory virus diseases
The complement system, a key component of innate immunity, provides the first line of
defense against bacterial infection; however, the COVID-19 pandemic has revealed that it …
defense against bacterial infection; however, the COVID-19 pandemic has revealed that it …
[HTML][HTML] Chronic lung inflammation and CK14+ basal cell proliferation induce persistent alveolar-bronchiolization in SARS-CoV-2-infected hamsters
C Li, N Xiao, W Song, AHC Lam, F Liu, X Cui, Z Ye… - Ebiomedicine, 2024 - thelancet.com
Background Post-acute sequalae of COVID-19 defines a wide range of ongoing symptoms
and conditions long after SARS-CoV-2 infection including respiratory diseases. The …
and conditions long after SARS-CoV-2 infection including respiratory diseases. The …
Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection
Advanced age is associated with an increased susceptibility to Coronavirus Disease
(COVID)-19 and more severe outcomes, although the underlying mechanisms are …
(COVID)-19 and more severe outcomes, although the underlying mechanisms are …
Natural Killer Cells Do Not Attenuate a Mouse-Adapted SARS-CoV-2-Induced Disease in Rag2−/− Mice
This study investigates the roles of T, B, and Natural Killer (NK) cells in the pathogenesis of
severe COVID-19, utilizing mouse-adapted SARS-CoV-2-MA30 (MA30). To evaluate this …
severe COVID-19, utilizing mouse-adapted SARS-CoV-2-MA30 (MA30). To evaluate this …
Persistent alveolar bronchiolization, interstitial fibrosis and impaired lung function post-exercise are features of long-COVID in SARS-CoV-2-Delta variant infected …
W Baumgärtner, L Heydemann, M Ciurkiewicz, T Störk… - 2024 - researchsquare.com
Long-term consequences of SARS-CoV-2 infection affect the life quality of millions of people
and pose a heavy burden on the public health sector. The underlying causes …
and pose a heavy burden on the public health sector. The underlying causes …