It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a
dinucleotide with natural 3′→ 5′-internucleotide linkages was reported. The main …

The chemical synthesis of DNA and RNA is universally carried out using nucleoside
phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus …

Historically, the discovery of the helical structure of DNA by Watson and Crick1 provided the
impetus to attempt the challenging synthesis of oligonucleotides of defined sequences …

We provide an overview of current approaches to DNA-based storage system design and of
accompanying synthesis, sequencing and editing methods. We also introduce and analyze …

Oligodeoxyribonucleoside phosphorothioates are isoelectronic analogues of natural
phosphodiesters in which one of the oxygen atoms that does not participate in the …

Modified oligodeoxynucleotides complementary to RNA of human immunodeficiency virus 1
(HIV-1) were tested for their ability to inhibit virally induced syncytium formation and …

Abstract Triethylammonium 1, 2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (2) was
coupled to the 5'terminus of oligodeoxynucleotides via hydrogen phosphonate solid support …

Several polysulfides were tested as potential sulfur-transfer reagents during the automated
synthesis of oligodeoxyribonucleoside phosphorothioates via the “deoxyribonucleoside …

RNA is often considered as being the vector for the transmission of genetic information from
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …

The biological importance and practical significance of phosphate esters and their
analogues have been the major driving forces for research in various areas of synthetic …