The term apoptosis or programmed cell death defines a genetically encoded cell death
program, which is morphologically and biochemically distinct from necrosis or accidental cell …

No inkling has been found of what happens in a cell when it becomes neoplastic, and how
this state of affairs is passed on when it multiplies. A favorite explanation has been that …

Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic
lesions in human cancers. To investigate the role of the p53 gene in mammalian …

A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a
complex with both mutant and wild-type~ 53 protein has been characterized, purified, and …

Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The
human cyclin A gene was identified as the site of integration of hepatitis B virus in a …

Point mutagenesis of the nuclear targeting sequence of nucleoplasmin has identified two
interdependent basic domains. These are separated by 10 intervening" spacer" amino acids …

G1/S and G2/M cell cycle checkpoints maintain genomic stability in eukaryotes in response
to genotoxic stress. We report here both genetic and functional evidence of a Gadd45 …

The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …

Cyclin A protein is synthesized and localized into the nucleus at the onset of S phase in
nontransformed mammalian flbroblasts. lnhibitlon of cyclin A synthesis or activity through …

Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene
amplification often occur during tumor progression, suggesting that they may be correlated …