The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Two billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb-infected
macrophages are likely to be sequestered inside the hypoxic environments of the …

Mycobacterium tuberculosis has an unusual outer membrane that lacks canonical porin
proteins for the transport of small solutes to the periplasm. We discovered that 3, 3-bis-di …

Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host
defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb) …

The mycobacterial PE/PPE proteins have attracted much interest since their formal
identification just over a decade ago. It has been widely speculated that these proteins may …

The cell wall is a major virulence factor of Mycobacterium tuberculosis and contributes to its
intrinsic drug resistance. Recently, cryo-electron microscopy showed that mycobacterial cell …

ESX‐5 is one of the five type VII secretion systems found in mycobacteria. These secretion
systems are also known as ESAT‐6‐like secretion systems. Here, we have determined the …

Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across
their unusual cell envelope. One of these systems, ESX-5, is only present in slow-growing …

Mycobacterial pathogens use specialized type VII secretion (T7S) systems to transport
crucial virulence factors across their unusual cell envelope into infected host cells. These …