Lymphoedema is the swelling of one or several parts of the body owing to lymph
accumulation in the extracellular space. It is often chronic, worsens if untreated, predisposes …

Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

The treatment of lymphatic anomaly, a rare devastating disease spectrum of mostly unknown
etiologies, depends on the patient manifestations. Identifying the causal genes will allow for …

Central conducting lymphatic anomaly (CCLA) due to congenital maldevelopment of the
lymphatics can result in debilitating and life-threatening disease with limited treatment …

Central conducting lymphatic anomaly (CCLA), characterized by the dysfunction of core
collecting lymphatic vessels including the thoracic duct and cisterna chyli, and presenting as …

Central conducting lymphatic anomaly (CCLA) is one of the complex lymphatic anomalies
characterized by dilated lymphatic channels, lymphatic channel dysmotility and distal …

Objective To evaluate the effect of the RAS-MAPK pathway inhibitor trametinib on medically
refractory chylous effusions in 3 hospitalized patients with Noonan syndrome. Study design …

Insulin resistance is a key event in type 2 diabetes onset and a major comorbidity of obesity.
It results from a combination of fat excess–triggered defects, including lipotoxicity and …

Now with full-color illustrations throughout, dozens of new review questions, and state-of-the-
art coverage of this fast-changing area, Pediatric Gastrointestinal and Liver Disease, 6th …

Abstract Purpose of Review Lymphatic disorders have received an increasing amount of
attention over the last decade. Sparked primarily by improved imaging modalities and the …