Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

Successful treatment of cancer remains a challenge, due to the unique pathophysiology of
solid tumors, and the predictable emergence of resistance. Traditional methods for cancer …

Copper is an essential microelement that plays an important role in a wide variety of
biological processes. Copper concentration has to be finely regulated, as any imbalance in …

Anti‐angiogenic therapy, targeting vascular endothelial cells (ECs) to prevent tumor growth,
has been attracting increasing attention in recent years, beginning with bevacizumab …

In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …

The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that
antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid …

This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to …

Low-molecular-weight vascular-disrupting agents (VDAs) cause a pronounced shutdown in
blood flow to solid tumours, resulting in extensive tumour-cell necrosis, while they leave the …

Cardiac hypertrophy is a multifactorial disease characterized by multiple molecular
alterations. One of these alterations is change in the activity of Akt, which plays a central role …

Human solid tumors are invariably less well‐oxygenated than the normal tissues from which
they arose. This so‐called tumor hypoxia leads to resistance to radiotherapy and anticancer …