[HTML][HTML] A review on medicinally important heterocyclic compounds
T Qadir, A Amin, PK Sharma… - The Open …, 2022 - openmedicinalchemistryjournal.com
Heterocyclic compounds account for the most prominent and diverse class of organic
compounds. A significant number of heterocyclic compounds have been synthesized up to …
compounds. A significant number of heterocyclic compounds have been synthesized up to …
Functional and pathological roles of AHCY
P Vizán, L Di Croce, S Aranda - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved
proteins in living organisms. AHCY catalyzes the reversible break of S …
proteins in living organisms. AHCY catalyzes the reversible break of S …
The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2
NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
Antivirals against the Chikungunya virus
V Battisti, E Urban, T Langer - Viruses, 2021 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …
Chemical approaches to carbocyclic nucleosides
AC Ojeda‐Porras, V Roy… - The Chemical Record, 2022 - Wiley Online Library
Nucleoside analogues are at the forefront of antiviral therapy for last decades. To circumvent
some of their limitations, based on their metabolism, and in order to improve their anti‐viral …
some of their limitations, based on their metabolism, and in order to improve their anti‐viral …
Small-molecule inhibitors of chikungunya virus: mechanisms of action and antiviral drug resistance
K Kovacikova, MJ van Hemert - Antimicrobial Agents and …, 2020 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has spread to more
than 60 countries worldwide. CHIKV infection leads to a febrile illness known as …
than 60 countries worldwide. CHIKV infection leads to a febrile illness known as …
Inhibitors of the Structural and Nonstructural Proteins of Alphaviruses
DS Metibemu, OS Adeyinka, J Falode… - ACS Infectious …, 2024 - ACS Publications
The Alphavirus genus includes viruses that cause encephalitis due to neuroinvasion and
viruses that cause arthritis due to acute and chronic inflammation. There is no approved …
viruses that cause arthritis due to acute and chronic inflammation. There is no approved …
Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues
CMM Benckendorff, VD Slyusarchuk… - Organic & …, 2022 - pubs.rsc.org
Analogues of the canonical nucleosides have a longstanding presence and proven
capability within medicinal chemistry and drug discovery research. The synthesis reported …
capability within medicinal chemistry and drug discovery research. The synthesis reported …
The Dimroth rearrangement in the synthesis of condensed pyrimidines–structural analogs of antiviral compounds
VА Mamedov, NА Zhukova, MS Kadyrova - Chemistry of Heterocyclic …, 2021 - Springer
The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines – Structural
Analogs of Antiviral Compounds | SpringerLink Skip to main content Advertisement …
Analogs of Antiviral Compounds | SpringerLink Skip to main content Advertisement …
Sindbis Macrodomain Poly-ADP-Ribose Hydrolase Activity Is Important for Viral RNA Synthesis
ABSTRACT ADP-ribosylation is a highly dynamic posttranslational modification frequently
studied in stress response pathways with recent attention given to its role in response to viral …
studied in stress response pathways with recent attention given to its role in response to viral …