Candida albicans cell-type switching and functional plasticity in the mammalian host

SM Noble, BA Gianetti, JN Witchley - Nature Reviews Microbiology, 2017 - nature.com
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most
prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal …

Growth of Candida albicans hyphae

PE Sudbery - Nature Reviews Microbiology, 2011 - nature.com
The fungus Candida albicans is often a benign member of the mucosal flora; however, it
commonly causes mucosal disease with substantial morbidity and in vulnerable patients it …

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota

S Höfs, S Mogavero, B Hube - Journal of microbiology, 2016 - Springer
The interaction between Candida albicans and its host cells is characterized by a complex
interplay between the expression of fungal virulence factors, which results in adherence …

Nonfilamentous C. albicans mutants are avirulent

HJ Lo, JR Köhler, B DiDomenico, D Loebenberg… - Cell, 1997 - cell.com
Candida albicans and Saccharomyces cerevisiae switch from a yeast to a filamentous form.
In Saccharomyces, this switch is controlled by two regulatory proteins, Ste12p and Phd1p …

Regulatory circuitry governing fungal development, drug resistance, and disease

RS Shapiro, N Robbins, LE Cowen - Microbiology and molecular …, 2011 - Am Soc Microbiol
Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

Transcriptional Response of Candida albicans upon Internalization by Macrophages

MC Lorenz, JA Bender, GR Fink - Eukaryotic cell, 2004 - Am Soc Microbiol
The opportunistic fungal pathogen Candida albicans is both a benign gut commensal and a
frequently fatal systemic pathogen. The interaction of C. albicans with the host's innate …

Candida albicans: A molecular revolution built on lessons from budding yeast

J Berman, PE Sudbery - Nature Reviews Genetics, 2002 - nature.com
Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, in immunocompromised patients …

Signal transduction cascades regulating fungal development and virulence

KB Lengeler, RC Davidson, C D'souza… - Microbiology and …, 2000 - Am Soc Microbiol
Cellular differentiation, mating, and filamentous growth are regulated in many fungi by
environmental and nutritional signals. For example, in response to nitrogen limitation …

Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans

S Biswas, P Van Dijck, A Datta - Microbiology and molecular …, 2007 - Am Soc Microbiol
Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …

White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating

MG Miller, AD Johnson - Cell, 2002 - cell.com
Discovered over a decade ago, white-opaque switching in the human fungal pathogen
Candida albicans is an alternation between two quasistable, heritable transcriptional states …