Cerebral palsy (CP) is the most prevalent, severe and costly motor disability of childhood.
Consequently, CP is a public health priority for prevention, but its aetiology has proved …

Cerebral white matter injury, characterised by loss of premyelinating oligodendrocytes (pre-
OLs), is the most common form of injury to the preterm brain and is associated with a high …

Major advances in understanding the cellular mechanisms of brain injury have presented a
host of potential targets for intervention. This is particularly true of hypoxic-ischemic injury …

OBJECTIVE. The goal was to test the hypothesis that extremes of Paco2 during the first 4
days after birth are associated with severe intraventricular hemorrhage (grades 3 and 4) …

With increased survival of preterm infants as young as 23 weeks gestation, maintaining
adequate respiration and corresponding oxygenation represents a clinical challenge in this …

Background: A new mode of surfactant administration without intubation-less invasive
surfactant administration (LISA)-has recently been described for premature infants …

Ventilatory management patterns in very low birth weight newborns, particularly iatrogenic
hypocapnia, have occasionally been implicated in perinatal brain damage. However, such …

Background: Episodes of hyperoxaemia and hypocapnia, which may contribute to brain
injury, occur unintentionally in severely asphyxiated neonates in the first postnatal hours …

Permissive hypercapnia, a strategy allowing high Paco 2, is widely used by neonatologists
to minimize lung damage in ventilated very low birth weight (VLBW) infants. While …

Excessive tidal volume (VT) can lead to lung injury, hypocarbia, and neurologic damage.
Volume guarantee (VG) uses exhaled VT as the control variable to reduce the risk of …