This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Plant antimicrobial peptides (AMPs) are a component of barrier defense system of plants.
They have been isolated from roots, seeds, flowers, stems, and leaves of a wide variety of …

Immunomodulatory peptides are a complex class of bioactive peptides that encompasses
substances with different mechanisms of action. Immunomodulatory peptides could also be …

Objectives To determine the antibacterial activity of small cyclic plant proteins, ie cyclotides,
and the importance of the surface exposed charged residues for activity. Methods Prototypic …

Here, we review potential determinants of the anticancer efficacy of innate immune peptides
(ACPs) for cancer cells. These determinants include membrane‐based factors, such as …

Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms and are promising candidates to treat infections caused by pathogenic bacteria to …

Several members of the Rubiaceae and Violaceae plant families produce a series of
cyclotides or macrocyclic peptides of 28–37 aa with an embedded cystine knot. The cyclic …

Cyclotides, a large family of cyclic peptides from plants, have a broad range of biological
activities, including insecticidal, cytotoxic, and anti-HIV activities. In all of these activities, cell …

Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide
bonds that confer them with exceptional stability. They were originally discovered in …

Cyclotides are plant-derived proteins that have a unique cyclic cystine knot topology and are
remarkably stable. Their natural function is host defense, but they have a diverse range of …