Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-
survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence …

Cancer tissues are composed of cancer cells and the surrounding stromal cells (eg,
fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and
molecules secreted by CAFs play an important role in tumor progression and metastasis …

Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment that are involved in multiple aspects of cancer progression and …

Multiple lines of evidence are indicating that cancer development and malignant
progression are not exclusively epithelial cancer cell-autonomous processes but may also …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a low
response to treatment and a five-year survival rate below 5%. The ineffectiveness of …

Highlights•ICIs have shifted the treatment paradigm to improve overall survival in advanced
SCLC.•The magnitude of immune-chemotherapy strategy is still modest. The …

Emerging evidence indicates that the induction of radiotherapy (RT) on the immunogenic
cell death (ICD) is not only dependent on its direct cytotoxic effect, changes in the tumor …