Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …

Nucleic acid aptamers are single-stranded DNA or RNA oligonucleotide sequences that
bind to a specific target molecule with high affinity and specificity through their ability to …

Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …

RNA is often considered as being the vector for the transmission of genetic information from
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …

The enzymatic co-polymerization of modified nucleoside triphosphates (dN* TPs and N*
TPs) is a versatile method for the expansion and exploration of expanded chemical space in …

Recent progresses in organic chemistry and molecular biology have allowed the emergence
of numerous new applications of nucleic acids that markedly deviate from their natural …

Highlights•Nucleic acid-based enzymes are highly potential biosensing and therapeutic
tools.•Description of the chemical methods designed to improve the properties of these …

Conspectus Nucleic acids are a distinct form of sequence-defined biopolymer. What sets
them apart from other biopolymers such as polypeptides or polysaccharides is their unique …

Highlights•Multiple DNA polymerases with divergent properties have been characterized
and engineered.•Varying characteristics of DNA polymerases result in specialized enzymes …

On average, mutations are deleterious to proteins. Mutations conferring new function to a
protein often come at the expense of protein folding or stability, reducing overall activity …