Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …

Background Primary central nervous system lymphoma (PCNSL) is a rare and distinct entity
within diffuse large B-cell lymphoma presenting with variable response rates probably to …

Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin
lymphoma, and there is limited research on its tumor microenvironment (TME) …

Background Primary central nervous system lymphoma (PCNSL) is an aggressive
extranodal non-Hodgkin lymphoma with a poor prognosis. We aimed to evaluate the …

To determine the overall tumor microenvironment (TME), characteristics, and transition
mechanisms in primary central nervous system lymphoma (PCNSL), we performed spatial …

Low back pain (LBP) is largely attributed to intervertebral disc degeneration (IVDD), of which
the endplate changes are an important component. However, the alterations in cell fate and …

Lymphomas are a heterogenous group of lymphoid neoplasms with a wide variety of clinical
presentations. Response to treatment and prognosis differs both between and within …

The evolution of lymphoma is a multifactorial process that leads to unavoidable lymphoma
heterogeneity in the form of genetic mutations, chromosomal translocations and other …

Background Diagnosis and prognostication of intra-axial brain tumors hinges on invasive
brain sampling, which carries risk of morbidity. Minimally-invasive sampling of proximal …