Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The model shown represents a polarized cell that has distinct leading and trailing edges.
This is a common feature of both fibroblastic and amoeboid motility. The leading edge points …

Cell polarity relies on the asymmetric organization of cellular components and structures.
Actin and microtubules are well suited to provide the structural basis for cell polarization …

The blood-brain barrier of Drosophila is established by surface glia, which ensheath the
nerve cord and insulate it against the potassium-rich hemolymph by forming intercellular …

Collective cell motility is an important aspect of several developmental and
pathophysiological processes. Despite its importance, the mechanisms that allow cells to be …

Dictyostelium discoideum, a unicellular organism capable of developing into a multicellular
structure, is a powerful model system to study a variety of biological processes. Because it is …

The directional movement of cells in a gradient of external stimulus is termed chemotaxis
and is important in many aspects of development and differentiated cell function …

Many types of cells are able to accurately sense shallow gradients of chemicals across their
diameters, allowing the cells to move toward or away from chemical sources. This …

In eukaryotic cells, phosphatidylinositol is subject to differential phosphorylation, resulting in
the production of seven distinct phosphatidylinositol phosphates, often referred to as …

GOALS: To review the literature on chondrocyte movements and to develop plausible
hypothesis for further work. DESIGN: Chondrocyte movements are herein defined as …