The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II
JD Hayes, DJ Pulford - Critical reviews in biochemistry and …, 1995 - Taylor & Francis
The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …
Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality?
CA Houghton, RG Fassett… - Oxidative medicine and …, 2016 - Wiley Online Library
The recognition that food‐derived nonnutrient molecules can modulate gene expression to
influence intracellular molecular mechanisms has seen the emergence of the fields of …
influence intracellular molecular mechanisms has seen the emergence of the fields of …
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi… - Biochemical and …, 1997 - Elsevier
The induction of phase II detoxifying enzymes is an important defense mechanism against
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
K Itoh, N Wakabayashi, Y Katoh, T Ishii… - Genes & …, 1999 - genesdev.cshlp.org
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
Activation of PERK following the accumulation of unfolded proteins in the endoplasmic
reticulum (ER) promotes translation inhibition and cell cycle arrest. PERK function is …
reticulum (ER) promotes translation inhibition and cell cycle arrest. PERK function is …
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative
damage. Nrf2 activity is opposed by the BTB/POZ domain protein Keap1. Keap1 is proposed …
damage. Nrf2 activity is opposed by the BTB/POZ domain protein Keap1. Keap1 is proposed …
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez, MK Kwak… - Proceedings of the …, 2001 - National Acad Sciences
Induction of phase 2 enzymes, which neutralize reactive electrophiles and act as indirect
antioxidants, appears to be an effective means for achieving protection against a variety of …
antioxidants, appears to be an effective means for achieving protection against a variety of …
Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles
K Itoh, N Wakabayashi, Y Katoh, T Ishii… - Genes to …, 2003 - Wiley Online Library
Abstract Background: Transcription factor Nrf2 regulates the expression of a set of
detoxifying and anti‐oxidant enzyme genes. Several lines of evidence suggest that …
detoxifying and anti‐oxidant enzyme genes. Several lines of evidence suggest that …
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and …
A Enomoto, K Itoh, E Nagayoshi, J Haruta… - Toxicological …, 2001 - academic.oup.com
Nrf2, which belongs to the basic leucine zipper (bZip) transcription factor family, has been
implicated as a key molecule involved in antioxidant-responsive element (ARE)-mediated …
implicated as a key molecule involved in antioxidant-responsive element (ARE)-mediated …
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway
SB Cullinan, JA Diehl - The international journal of biochemistry & cell …, 2006 - Elsevier
In the broadest sense, cellular stress describes conditions wherein cells encounter and react
to a 'non-normal'state. Perturbations may originate through both extracellular and …
to a 'non-normal'state. Perturbations may originate through both extracellular and …