Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high
predisposition to develop both benign and malignant tumours. Although many …

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a worldwide
incidence of∼ 1 per 2500 to 3000 individuals. Caused by a germ-line–inactivating mutation …

The skeleton is frequently affected in individuals with neurofibromatosis type 1, and some of
these bone manifestations can result in significant morbidity. The natural history and …

Oral health status is jeopardized in patients with neurofibromatosis (NF) type-1 (NF-1). The
aim of the present study was to comprehensively review the oral manifestations in NF-1 …

Object Skull defects, including sphenoid dysplasia and calvarial defects, are rare but distinct
findings in patients with neurofibromatosis Type 1 (NF1). The underlying pathophysiology is …

The RASopathies comprise an ever-growing number of clinical syndromes resulting from
germline mutations in components of the RAS/MAPK signaling pathway. While multiple …

Simple Summary We herein describe the relevance of Vitamin D for human health, with a
special focus on its role in Neurofibromatosis type 1 (NF1) disease. Indeed, epidemiological …

Abstract Background Neurofibromatosis type 1 (NF1) is a common, autosomal dominant
tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor …

Postfracture tibial nonunion (pseudoarthrosis) leads to lifelong disability in patients with
neurofibromatosis type I (NF1), a disorder caused by mutations in the NF1 gene. To …

Objective: Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition
syndrome with a tendency to develop peripheral nerve sheath tumors (PNST). Plexiform …