Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Abstract Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in
a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However …

Background and Aims Circulating albumin in cirrhosis can be dysfunctional because of
accumulating structural damages, leading to the concept of effective albumin concentration …

Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …

Background and Aims HCC is a leading cause of cancer‐related deaths globally with poor
outcome and limited therapeutic options. Although the myelocytomatosis (MYC) oncogene is …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …

Background: ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription
factor containing an N-terminal kinase domain and a C-terminal transcriptional activation …

The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2
(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its …