Therapeutic interventions after spinal cord injury

S Thuret, LDF Moon, FH Gage - Nature Reviews Neuroscience, 2006 - nature.com
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms

L Zhang, C Steinmaus, DA Eastmond, XK Xin… - … Research/Reviews in …, 2009 - Elsevier
Formaldehyde is an economically important chemical, to which more than 2 million US
workers are occupationally exposed. Substantially more people are exposed to …

Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial

A Mackay-Sim, F Feron, J Cochrane… - Brain, 2008 - academic.oup.com
Olfactory ensheathing cells show promise in preclinical animal models as a cell
transplantation therapy for repair of the injured spinal cord. This is a report of a clinical trial of …

Olfactory mucosa autografts in human spinal cord injury: a pilot clinical study

C Lima, J Pratas-Vital, P Escada… - The journal of spinal …, 2006 - Taylor & Francis
Abstract Background/Objective: Olfactory mucosa is a readily accessible source of olfactory
ensheathing and stem-like progenitor cells for neural repair. To determine the safety and …

EdU, a new thymidine analogue for labelling proliferating cells in the nervous system

F Chehrehasa, ACB Meedeniya, P Dwyer… - Journal of neuroscience …, 2009 - Elsevier
Labelling and identifying proliferating cells is central to understanding neurogenesis and
neural lineages in vivo and in vitro. We present here a novel thymidine analogue, ethynyl …

The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties

B Delorme, E Nivet, J Gaillard, T Häupl… - Stem cells and …, 2010 - liebertpub.com
We previously identified multipotent stem cells within the lamina propria of the human
olfactory mucosa, located in the nasal cavity. We also demonstrated that this cell type …

Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury

C Lima, P Escada, J Pratas-Vital… - … and neural repair, 2010 - journals.sagepub.com
Background/objective. Basic science advances in spinal cord injury (SCI) are leading to
novel clinical approaches. The authors report a prospective, uncontrolled pilot study of the …

Lineage-specific distribution of high levels of genomic

A Ruzov, Y Tsenkina, A Serio, T Dudnakova, J Fletcher… - Cell research, 2011 - nature.com
Methylation of cytosine is a DNA modification associated with gene repression. Recently, a
novel cytosine modification, 5-hydroxymethylcytosine (5-hmC) has been discovered. Here …

Disease-specific, neurosphere-derived cells as models for brain disorders

N Matigian, G Abrahamsen… - Disease models & …, 2010 - journals.biologists.com
There is a pressing need for patient-derived cell models of brain diseases that are relevant
and robust enough to produce the large quantities of cells required for molecular and …

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

JS Park, B Koentjoro, D Veivers… - Human molecular …, 2014 - academic.oup.com
Abstract Human ATP13A2 (PARK9), a lysosomal type 5 P-type ATPase, has been
associated with autosomal recessive early-onset Parkinson's disease (PD). ATP13A2 …