Transforming growth factor (TGF)-β is a multifunctional peptide growth factor that has a vital
role in the regulation of cell growth, differentiation, inflammation, and repair in a variety of …

Background New biomarkers are needed to detect pleural mesothelioma at an earlier stage
and to individualize treatment strategies. We investigated whether fibulin-3 in plasma and …

The human fibulin family consists of seven complex extracellular glycoproteins originally
characterized as components of elastic fibers in connective tissue. However, beyond its …

Ovarian cancer is the leading cause of death among gynaecological malignancies.
Extracellular matrix (ECM) can affect drug resistance by preventing the penetration of the …

Fibroblasts can be directly reprogrammed into cardiomyocytes, endothelial cells or smooth
muscle cells. Here we report the reprogramming of mouse tail-tip fibroblasts simultaneously …

Pancreatic cancer is a lethal disease that is difficult to diagnose at early stages when
curable treatments are effective. Biomarkers that can improve current pancreatic cancer …

Background High-grade soft tissue sarcomas are a heterogeneous, complex group of
aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue …

Ovarian cancer is the most lethal gynecological malignancy. Multiple drug resistance (MDR)
development leads to resistance of cancer cells to chemotherapy. Microarray methods can …

Background: Fibulin-3 (FBLN3) was recently presented as a promising novel biomarker for
malignant pleural mesothelioma (MPM), warranting independent validation studies …

Malignant gliomas are highly invasive and chemoresistant brain tumors with extremely poor
prognosis. Targeting of the soluble factors that trigger invasion and resistance, therefore …