Nicotinamide riboside is a precursor to the important cofactor nicotinamide adenine
dinucleotide and has elicited metabolic benefits in multiple preclinical studies. In 2016, the …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …

NAD+, the essential metabolite involved in multiple reactions such as the regulation of
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …

Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and
thinking skills by affecting the hippocampus and entorhinal cortex. The main …

The restriction of calories, branched-chain amino acids, and methionine have all been
shown to extend lifespan in model organisms. Recently, glycine was found to boost …

The gut microbiota (GM) and its metabolites affect the host nervous system and are involved
in the pathogeneses of various neurological diseases. However, the specific GM alterations …

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

Simple Summary Alzheimer's disease (AD) is a progressive disease, where dementia
symptoms gradually worsen. The causes of AD are complex and are characterized by …

Advancing age and many disease states are associated with declines in nicotinamide
adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ …