There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior
and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from …

The recognition that the increase of plasma triglyceride rich lipoproteins (TRLs) is
associated with multiple alterations of other lipoproteins species that are potentially …

Insulin resistance and type 2 diabetes are associated with a clustering of interrelated plasma
lipid and lipoprotein abnormalities, which include reduced HDL cholesterol, a predominance …

Hypertriglyceridemia is a common lipid abnormality in persons with visceral obesity,
metabolic syndrome and type 2 diabetes. Hypertriglyceridemia typically occurs in …

The apolipoprotein B containing lipoproteins VLDL, IDL, and LDL exhibit variation in their
structure, function, and metabolism. These major lipoprotein classes can be fractionated into …

The purpose of this article is to review the basic and clinical science relating plasma
triglycerides and cardiovascular disease. Although many aspects of the basic physiology of …

Low density lipoprotein (LDL) is known to bind to arterial wall proteoglycans (APG), an
interaction which may initiate cholesterol deposition in the arterial wall. The objective of this …

Small dense low density lipoprotein (LDL) particles have altered apolipoprotein (apo) B
conformation and lowered affinity for the LDL receptor (J. Biol. Chem. 1994. 269: 511–519) …

Abnormalities in insulin and glucose metabolism do not seem to entirely account for the high
frequency of cardiovascular disease in patients with type 2 diabetes mellitus. An important …