The mucosal surfaces of the human body are typically colonized by polymicrobial
communities seeded in infancy and are continuously shaped by environmental exposures …

Particulate matter (PM) air pollution is closely related to lower respiratory infections (LRIs).
However, the global LRI burden attributable to PM remains unclear. Here, we provide a …

Childhood asthma develops from a complex interaction among host and environmental
factors in early life. Birth cohort studies have provided valuable insight into asthma risk …

Background Lower respiratory infections (LRIs) cause a substantial mortality, morbidity and
economic burden. The present study reported the global, regional and national burden of …

BACKGROUND: There is a large, unexplained variation in the frequency of childhood
infections. We described incidence and risk factors of infections in early childhood …

Background Preschool children with recurrent wheezing are heterogeneous, with differing
responses to respiratory viral infections. Although neutrophils are crucial for host defense …

Background We previously showed an association between neonatal bacterial airway
colonisation and increased risk of persistent wheeze/asthma until age 5 years. Here, we …

The Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) mother-child
cohorts have provided a foundation of 25 years of research on the origins, prevention, and …

Over the past two decades, several studies have positioned early-life microbial exposure as
a key factor for protection or susceptibility to respiratory diseases. Birth cohorts have …

Background Airway microbiota may play an important role in regulating the immune
response related to allergic respiratory diseases. A molecular-based approach was used to …