The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Background A multitude of recent studies has observed common epigenetic changes
develop in tumour cells of multiple lineages following exposure to stresses such as hypoxia …

Background: Papillary renal cell carcinoma (pRCC) was the 2 nd most common subtype,
accounting for approximately 15% incidence of renal cell carcinoma (RCC). Immune related …

Asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis
(IPF) are three serious lung inflammatory diseases. The understanding of the pathogenesis …

Environmental exposure to arsenic, a well-established carcinogen linked to a number of
human cancers, is a public health concern in many areas of the world. Despite extensive …

In the last years, we have witnessed remarkable advances in targeted therapies for cancer
patients. There is a growing effort to either replace or reduce the dose of unspecific, systemic …

It is well established that cancer cells exhibit alterations in chromatin structure and
accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic …

Objective Aberrant epigenetic remodeling represents a molecular hallmark in lung
adenocarcinoma (LUAD). We aim to investigate the biological roles of SETDB2 and its …

Objective Clear cell renal cell carcinoma (ccRCC) is one of the deadly diseases with poor
metastatic disease prognosis. There is an urgent need to explore the potential molecular …

The histone H3K9 methyltransferase SETDB2 is involved in cell cycle dysregulation in acute
leukemia and has oncogenic roles in gastric cancer. In our study, we found that SETDB2 …