A functional adaptive immune response is the major determinant for clearance of hepatitis C
virus (HCV) infection. However, in the majority of patients, this response fails and persistent …

Over the past two decades, much has been learned about how human viruses evade T cell
immunity to establish persistent infection. The lessons are particularly relevant to two …

Background Chronic HCV infection is a leading cause of liver-related morbidity globally. The
innate and adaptive immune responses are thought to be important in determining viral …

Globally, about 1% of pregnant women are persistently infected with the hepatitis C virus
(HCV). Mother-to-child transmission of HCV occurs in 3–5% of pregnancies and accounts for …

Approximately 500 million people are chronically infected with the hepatitis B virus (HBV) or
hepatitis C virus (HCV) worldwide and are thus at high risk of progressive liver disease …

Background and Aims During chronic hepatitis C virus (HCV) infection, CD8+ T-cells
become functionally exhausted, undergoing progressive phenotypic changes, ie …

Antiviral CD8+ T cells are a key component of the adaptive immune response against HCV,
but their impact on viral control is influenced by preexisting viral variants in important target …

Hepatitis C virus (HCV) afflicts 170 million people worldwide, 2%–3% of the global
population, and kills 350 000 each year. Prophylactic vaccination offers the most realistic …

Abstract Hepatitis C Virus (HCV) is a viral infection posing a severe global threat that left
untreated progresses to end‐stage liver disease, including cirrhosis and hepatocellular …

Hepatitis C virus (HCV) is a small, enveloped RNA virus. The number of HCV-infected
individuals worldwide is estimated to be approximately 200 million. The vast majority of HCV …