Skin wound healing aims to repair and restore tissue through a multistage process that
involves different cells and signalling molecules that regulate the cellular response and the …

Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

As one of major chronic complications of diabetes, diabetic foot ulcer (DFU) is the main
cause of disability and death. The clinical diagnosis and prognosis of DFU is inadequate …

Diabetic foot ulceration (DFU) is a chronic complication of diabetes that is characterized by
impaired wound healing in the lower extremities. DFU remains a major clinical challenge …

Therapeutics utilizing siRNA are currently limited by the availability of safe and effective
delivery systems. Cutaneous diseases, specifically ones with significant genetic components …

In human cells oxygen levels are 'sensed'by a set of ferrous iron and 2-oxoglutarate
dependent dioxygenases. These enzymes regulate a broad range of cellular and systemic …

A system has been engineered for temporally controlled delivery of siRNA from
biodegradable tissue regenerative scaffolds. Therapeutic application of this approach to …

Significance: Chronic wounds remain a significant public health problem. Alterations in
normal physiological processes caused by aging or diabetes lead to impaired tissue repair …

Wounds, both chronic and acute, continue to be a tremendous socioeconomic burden. As
such, technologies drawn from many disciplines within science and engineering are …

Polymer hydrogels consist of a three-dimensional (3D) structure with cross-linked networks
rich in a huge amount of water through hydrogen-bonding interactions, making them highly …