Advances and challenges in metatranscriptomic analysis

M Shakya, CC Lo, PSG Chain - Frontiers in genetics, 2019 - frontiersin.org
Sequencing-based analyses of microbiomes have traditionally focused on addressing the
question of community membership and profiling taxonomic abundance through amplicon …

Metagenomics, metatranscriptomics, and metabolomics approaches for microbiome analysis: supplementary issue: bioinformatics methods and applications for big …

V Aguiar-Pulido, W Huang… - Evolutionary …, 2016 - journals.sagepub.com
Microbiomes are ubiquitous and are found in the ocean, the soil, and in/on other living
organisms. Changes in the microbiome can impact the health of the environmental niche in …

[HTML][HTML] Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics

T Ojala, AE Häkkinen, E Kankuri, M Kankainen - Trends in Genetics, 2023 - cell.com
Metatranscriptomics refers to the analysis of the collective microbial transcriptome of a
sample. Its increased utilization for the characterization of human-associated microbial …

Metatranscriptomics for the human microbiome and microbial community functional profiling

Y Zhang, KN Thompson, T Branck, Y Yan… - Annual Review of …, 2021 - annualreviews.org
Shotgun metatranscriptomics (MTX) is an increasingly practical way to survey microbial
community gene function and regulation at scale. This review begins by summarizing the …

SAMSA2: a standalone metatranscriptome analysis pipeline

ST Westreich, ML Treiber, DA Mills, I Korf, DG Lemay - BMC bioinformatics, 2018 - Springer
Background Complex microbial communities are an area of growing interest in biology.
Metatranscriptomics allows researchers to quantify microbial gene expression in an …

IMP: a pipeline for reproducible reference-independent integrated metagenomic and metatranscriptomic analyses

S Narayanasamy, Y Jarosz, EEL Muller… - Genome biology, 2016 - Springer
Existing workflows for the analysis of multi-omic microbiome datasets are lab-specific and
often result in sub-optimal data usage. Here we present IMP, a reproducible and modular …

Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal …

A Zou, K Nadeau, X Xiong, PW Wang, JK Copeland… - Microbiome, 2022 - Springer
Background The emergence of antimicrobial resistance is a major threat to global health
and has placed pressure on the livestock industry to eliminate the use of antibiotic growth …

A deep learning approach reveals unexplored landscape of viral expression in cancer

A Elbasir, Y Ye, DE Schäffer, X Hao… - Nature …, 2023 - nature.com
About 15% of human cancer cases are attributed to viral infections. To date, virus expression
in tumor tissues has been mostly studied by aligning tumor RNA sequencing reads to …

Metatranscriptomic analysis of diverse microbial communities reveals core metabolic pathways and microbiome-specific functionality

Y Jiang, X Xiong, J Danska, J Parkinson - Microbiome, 2016 - Springer
Background Metatranscriptomics is emerging as a powerful technology for the functional
characterization of complex microbial communities (microbiomes). Use of unbiased RNA …

Microbial bioinformatics for food safety and production

W Alkema, J Boekhorst, M Wels… - Briefings in …, 2016 - academic.oup.com
In the production of fermented foods, microbes play an important role. Optimization of
fermentation processes or starter culture production traditionally was a trial-and-error …