This review covers fundamental developments in liquid chromatography during the period of
December 1987 through approximately December 1989. This year for the first time there are …

Methotrexate (MTX), a folic acid derivative, is a potent anticancer used for treatment of
different malignancies, but possible initiation of drug resistance to MTX by cancer cells has …

The applications of various pre-column derivatization reactions are presented in this review.
The reactions are particularly applicable for various detection techniques [ultraviolet (UV) …

Methotrexate (MTX) has been widely used at low dose for the treatment of different diseases
including rheumatoid arthritis. MTX might be present in plasma in free form, and in blood …

Methotrexate (MTX) is an anticancer agent that is widely used in a variety of human cancers
including primary central nervous system lymphoma (PCNSL). Important pharmacological …

Objective Development and validation of a selective and sensitive LCMS method for the
determination of methotrexate polyglutamates in dried blood spots (DBS). Methods DBS …

For more than four decades, scientists and researchers have relied on the Advances in
Chromatography series for the most up-to-date information on a wide range of …

ABSTRACT A simple and sensitive HPLC method has been developed for the determination
of methotrexate (MTX) and its major metabolites, 7‐hydroxymethotrexate (7‐OH‐MTX) and …

A sensitive and simple method for the methotrexate quantification was developed using
aminopterin as internal standard. Methotrexate is an anticancer agent that is widely used in …

A simple, rapid and sensitive reversed-phase high performance liquid chromatography
(HPLC) method has been developed for the determination of methotrexate in human serum …