Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

This review is the first to collate and summarize main data on named and unnamed
rearrangement reactions of peroxides. It should be noted, that in the chemistry of peroxides …

Artemisinin combination therapies (ACTs) have been used as the first‐line treatments
against Plasmodium falciparum malaria for decades. Recent advances in chemical …

Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials
based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance …

In spite of the recent increase in endoperoxide antimalarials under development, it remains
unclear if all these chemotypes share a common mechanism of action. This is important …

Therapeutics with novel modes of action and a low risk of generating resistance are urgently
needed to combat drug-resistant Plasmodium falciparum malaria. Here, we report that the …

Despite a significant decline in morbidity and mortality over the last two decades, in 2018
there were 228 million reported cases of malaria and 405000 malaria-related deaths …

Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …

Bridged aminoperoxides, for the first time, were investigated for the in vitro antimalarial
activity against the chloroquine‐resistant Plasmodium falciparum strain K1 and for their …

The ozonides are one of the most advanced drug classes in the antimalarial development
pipeline and were designed to improve on limitations associated with current front-line …