Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

β-Peptides are a class of polyamides that have been demonstrated to adopt a variety of
helical conformations. Recently, a series of amphiphilic L+ 2 helical β-peptides were …

Substantial progress has been made in the synthesis and characterization of various
oligomeric molecules capable of autonomous folding to well-defined, repetitive secondary …

We have examined the intramolecular hydrogen bonding behavior of simple ß-and-amino
acid derivatives as a prelude to efforts to design unnatural polyamides that will adopt …

Polypeptides composed of 30 amino acid residues or less typically do not adoptwell-defined
conformations in aqueous solution; rather they adopt an ensemble of energetically similar …

A family of novel oligomers based on the anthranilamide nucleus has been prepared and
shown to form well-defined secondary structural features. 1H NMR and X-ray …

What I cannot create, I do not understand. Richard P. Feynman β-Sheets consist of
extended polypeptide strands (β-strands) connected by a network of hydrogen bonds and …