Recent decades have witnessed striking growth in the number of older adults both in the
United States and throughout much of the world, largely due to improved public health …

Review on how dangerous atherosclerotic plaques form and the critical role for defective
phagocytic clearance (or “efferocytosis”) of apoptotic macrophages in these lesions …

Macrophage apoptosis in advanced atheromata, a key process in plaque necrosis, involves
the combination of ER stress with other proapoptotic stimuli. We show here that oxidized …

Oxidative stress has been implicated in the pathogenesis of cardiovascular diseases,
including myocardial hypertrophy and infarction. Although impairment of antioxidant defense …

Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in
cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These …

Age-associated decline in antioxidant potential and accumulation of reactive
oxygen/nitrogen species are primary causes for multiple health problems, including …

Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging
mammals and are frequently associated with leptin resistance and increased plasma leptin …

Poststroke depression (PSD) in elderly patients has been considered the most common
neuropsychiatric consequence of stroke up to 6–24 months after stroke onset. When …

Objective It is well known that ageing is associated with several hormonal alterations.
However, the consequence of ageing on the endocrine function of adipose tissue is not fully …

As the average human lifespan extends and medical care improves, there are more
individuals above the age of 80 years who have a high quality of life. However, these very …