Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy
Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
Signaling and function of interleukin-2 in T lymphocytes
SH Ross, DA Cantrell - Annual review of immunology, 2018 - annualreviews.org
The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …
Sepsis: inflammation is a necessary evil
Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …
available other than ICU treatment. The patient outcome is determined by a complex …
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
S Muhammad, T Fan, Y Hai, Y Gao, J He - Molecular Cancer, 2023 - Springer
Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …
responses. Their function and expression in the tumor microenvironment make them …
The role of cytokines in the regulation of NK cells in the tumor environment
GM Konjević, AM Vuletić, KMM Martinović, AK Larsen… - Cytokine, 2019 - Elsevier
Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …
of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms …
Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation
Influenza in humans is often accompanied by gastroenteritis-like symptoms such as
diarrhea, but the underlying mechanism is not yet understood. We explored the occurrence …
diarrhea, but the underlying mechanism is not yet understood. We explored the occurrence …
The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects
F Dehkhoda, CMM Lee, J Medina… - Frontiers in …, 2018 - frontiersin.org
The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …
many other important biological functions including regulating metabolism and controlling …
Multiomic analysis of cytokines in immuno-oncology
V Jurisic - Expert review of proteomics, 2020 - Taylor & Francis
Introduction: Cytokines are a diverse group of peptides produced by different cell types
including cancer cells and various subpopulations of immune system cells. They exert their …
including cancer cells and various subpopulations of immune system cells. They exert their …
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …
LPS-induced cytokine production in human monocytes and macrophages
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …
immune-activating stimuli known. Here we review the current understanding of LPS effects …