Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Clinical and translational research has played a major role in advancing our understanding
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …

Antiadhesion barriers such as films and hydrogels used to wrap repaired tendons are
important for preventing the formation of adhesion tissue after tendon surgery. However …

Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Bronchopulmonary dysplasia (BPD) is a major complication in prematurely born infants.
Pulmonary hypertension (PH) associated with BPD (BPD-PH) is characterized by alveolar …

Right ventricular (RV) heart failure is the leading cause of death in pulmonary arterial
hypertension (PAH). Peroxisome proliferator–activated receptor γ (PPARγ) acts as a …

Objectives With age, bone marrow mesenchymal stem cells (BMSC) have reduced ability of
differentiating into osteoblasts but have increased ability of differentiating into adipocytes …

Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of
the lung is progressively replaced by fibrotic scars. Myofibroblasts are the effector cells that …

Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …