Fluorescence optical imaging in anticancer drug delivery
In the past several decades, nanosized drug delivery systems with various targeting
functions and controlled drug release capabilities inside targeted tissues or cells have been …
functions and controlled drug release capabilities inside targeted tissues or cells have been …
[HTML][HTML] HPMA copolymer-based nanomedicines in controlled drug delivery
Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
Stimuli‐sensitive linear–dendritic block copolymer–drug prodrug as a nanoplatform for tumor combination therapy
H Cai, P Tan, X Chen, M Kopytynski, D Pan… - Advanced …, 2022 - Wiley Online Library
Linear–dendritic block copolymer (LDBCs) are highly attractive candidates for smart drug‐
delivery vehicles. Herein, an amphiphilic poly [(ethylene glycol) methyl ether methacrylate] …
delivery vehicles. Herein, an amphiphilic poly [(ethylene glycol) methyl ether methacrylate] …
[HTML][HTML] Polymer-based prodrugs: improving tumor targeting and the solubility of small molecule drugs in cancer therapy
S Dragojevic, JS Ryu, D Raucher - Molecules, 2015 - mdpi.com
The majority of anticancer drugs have poor aqueous solubility, produce adverse effects in
healthy tissue, and thus impose major limitations on both clinical efficacy and therapeutic …
healthy tissue, and thus impose major limitations on both clinical efficacy and therapeutic …
The light at the end of the tunnel—second generation HPMA conjugates for cancer treatment
It is almost four decades since N-(2-hydroxypropyl) methacrylamide (HPMA)-based
copolymers arose as drug carriers. Although fundamentals have been established and …
copolymers arose as drug carriers. Although fundamentals have been established and …
HPMA copolymer–drug conjugates with controlled tumor‐specific drug release
Over the past few decades, numerous polymer drug carrier systems are designed and
synthesized, and their properties are evaluated. Many of these systems are based on water …
synthesized, and their properties are evaluated. Many of these systems are based on water …
Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic
The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded
with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were …
with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were …
Enzyme/pH-sensitive polyHPMA–DOX conjugate as a biocompatible and efficient anticancer agent
In this study, to enhance the therapeutic function and reduce the side-effects of doxorubicin
(DOX), a biodegradable N-(2-hydroxypropyl) methacrylamide (HPMA) polymer–DOX …
(DOX), a biodegradable N-(2-hydroxypropyl) methacrylamide (HPMA) polymer–DOX …
Highway to success—developing advanced polymer therapeutics
MB Ashford, RM England, N Akhtar - Advanced Therapeutics, 2021 - Wiley Online Library
Polymer therapeutics are advancing as an important class of drugs. Polymers have already
demonstrated their value in extending the half‐life of proteins. They show great potential as …
demonstrated their value in extending the half‐life of proteins. They show great potential as …
PEGylated N-(2 hydroxypropyl) methacrylamide-doxorubicin conjugate as pH-responsive polymeric nanoparticles for cancer therapy
Biodegradable and tumor-micro-environmental responsive polymers are desired for
targeted anticancer drug delivery. In this regard, development of pH sensitive drug delivery …
targeted anticancer drug delivery. In this regard, development of pH sensitive drug delivery …