Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines

RC Harris, T Sumner, GM Knight… - Human vaccines & …, 2016 - Taylor & Francis
Mathematical models are useful for assessing the potential epidemiological impact of future
tuberculosis (TB) vaccines. We conducted a systematic review of mathematical models …

TB vaccine development and the End TB Strategy: importance and current status

HA Fletcher, L Schrager - Transactions of the Royal Society of …, 2016 - academic.oup.com
TB is now the leading, global cause of death due to a single infectious microbe. To achieve
the End TB vision of reducing TB by 90% by 2035 we will need new interventions. The …

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

A Arbues, JI Aguilo, J Gonzalo-Asensio, D Marinova… - Vaccine, 2013 - Elsevier
The development of a new tuberculosis vaccine is an urgent need due to the failure of the
current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an …

Impact and cost-effectiveness of new tuberculosis vaccines in low-and middle-income countries

GM Knight, UK Griffiths, T Sumner… - Proceedings of the …, 2014 - National Acad Sciences
To help reach the target of tuberculosis (TB) disease elimination by 2050, vaccine
development needs to occur now. We estimated the impact and cost-effectiveness of …

Cost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India

RC Harris, M Quaife, C Weerasuriya, GB Gomez… - Nature …, 2022 - nature.com
Abstract The M72/AS01E tuberculosis vaccine showed 50%(95% CI: 2–74%) efficacy in a
phase 2B trial in preventing active pulmonary tuberculosis disease, but potential cost …

[图书][B] Free market tuberculosis: Managing epidemics in post-Soviet Georgia

E Koch - 2013 - muse.jhu.edu
summary The Soviet health care infrastructure and its tuberculosis-control system were
anchored in biomedicine, but the dire resurgence of tuberculosis at the end of the twentieth …

The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China

CK Weerasuriya, RC Harris, CF McQuaid, F Bozzani… - BMC medicine, 2021 - Springer
Background Despite recent advances through the development pipeline, how novel
tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant …

How can mathematical models advance tuberculosis control in high HIV prevalence settings?

RMGJ Houben, DW Dowdy, A Vassall… - … of tuberculosis and …, 2014 - ingentaconnect.com
Existing approaches to tuberculosis (TB) control have been no more than partially
successful in areas with high human immunodeficiency virus (HIV) prevalence. In the …

A review of clinical models for the evaluation of human TB vaccines

MK O'Shea, H McShane - Human vaccines & immunotherapeutics, 2016 - Taylor & Francis
While much progress has been made in the fight against the scourge of tuberculosis (TB),
we are still some way from reaching the ambitious targets of eliminating it as a global public …

Tuberculosis vaccines: progress and challenges

AM Checkley, H McShane - Trends in pharmacological sciences, 2011 - cell.com
An effective tuberculosis (TB) vaccine could have a significant impact on the current TB
pandemic. The past decade has seen sustained global investment into reaching this goal; …