T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …

Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Regulatory T cells (Tregs) control immune homeostasis and prevent exacerbated immune
responses, and can be used as cell therapy to dampen a variety of autoimmune or …

Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …

Despite three decades of research to its name and increasing interest in immunotherapies
that target it, LAG-3 remains an elusive co-inhibitory receptor in comparison to the well …

Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions
and maintain peripheral self-tolerance, playing an essential role in maintaining immune …

The immune system has a well‐established contribution to tissue homeostasis and wound
healing. However, in many cases immune responses themselves can cause severe tissue …