Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …
disease caused by tobacco smoking in genetically susceptible individuals has been …
Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective
Exposure to environmental organic pollutants has triggered significant ecological impacts
and adverse health outcomes, which have been received substantial and increasing …
and adverse health outcomes, which have been received substantial and increasing …
Metabolomics for investigating physiological and pathophysiological processes
DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …
Tracking complex mixtures of chemicals in our changing environment
Chemicals have improved our quality of life, but the resulting environmental pollution has
the potential to cause detrimental effects on humans and the environment. People and biota …
the potential to cause detrimental effects on humans and the environment. People and biota …
[HTML][HTML] A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
J Sun, R Fang, H Wang, DX Xu, J Yang, X Huang… - Environment …, 2022 - Elsevier
Humans are exposed to an ever-increasing number of environmental toxicants, some of
which have gradually been elucidated to be important risk factors for metabolic diseases …
which have gradually been elucidated to be important risk factors for metabolic diseases …
Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
Emerging applications of metabolomics in drug discovery and precision medicine
DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics
Novel metabolites distinct from canonical pathways can be identified through the integration
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …
[HTML][HTML] The skin aging exposome
J Krutmann, A Bouloc, G Sore, BA Bernard… - Journal of …, 2017 - Elsevier
The term “exposome” describes the totality of exposures to which an individual is subjected
from conception to death. It includes both external and internal factors as well as the human …
from conception to death. It includes both external and internal factors as well as the human …
The contribution of the exposome to the burden of cardiovascular disease
Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …
the Global Burden of Disease project, indicate that chronic non-communicable diseases …