Breast cancer is the most common female malignancy, but the mechanisms regulating gene
expression leading to its development are complex. In recent years, as epigenetic research …

Simple Summary RBM22 is a gene that encodes an essential RNA-Binding Protein involved
in pre-mRNA splicing and transcription, with a DNA-binding function. This dual RNA/DNA …

STK19 was originally identified as a manganese-dependent serine/threonine-specific
protein kinase, but its function has been highly debated. Here, the crystal structure of STK19 …

The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support
growth and metastasis remain largely unknown, and it has become increasingly apparent …

Abstract RNA-binding protein 47 (RBM47) is required for embryonic endoderm
development, but a role in adult intestine is unknown. We studied intestine-specific Rbm47 …

Clear cell renal cell carcinoma (ccRCC) accounts for~ 75% of kidney cancers. The biallelic
inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is the truncal driver …

Background Single-cell RNA sequencing (scRNA-seq) has been widely applied to dissect
cellular heterogeneity in normal and diseased skin. Sebaceous glands, essential skin …

Splicing factors (SFs) are proteins that control the alternative splicing (AS) of RNAs, which
have been recognized as new cancer hallmarks. Their dysregulation has been found to be …

RNA binding proteins have the critical role in renal cell carcinoma (RCC) progression.
However, the role of RBM47 in RCC has not been elucidated. In this study, we found that …

RNA-binding proteins (RBPs) are involved in the regulation of RNA splicing, stability, and
localization. How RBPs control the development of atherosclerosis, is not fully understood …