A century ago, Cajal noted striking similarities between the neural circuits that underlie
vision in vertebrates and flies. Over the past few decades, structural and functional studies …

Intravital microscopy has become increasingly popular over the past few decades because it
provides high-resolution and real-time information about complex biological processes …

Visual stimuli can evoke complex behavioral responses, but the underlying streams of
neural activity in mammalian brains are difficult to follow because of their size. Here, I review …

Retinal degenerations are a heterogeneous group of diseases characterized by death of
photoreceptors and progressive loss of vision. Retinal degenerations are a major cause of …

Reporter-based assays underlie many high-throughput screening (HTS) platforms, but most
are limited to in vitro applications. Here, we report a simple whole-organism HTS method for …

Photoreceptor degeneration is a common cause of inherited blindness worldwide. We have
identified a blind zebrafish mutant with rapid degeneration of cone photoreceptors caused …

Cell type–specific green fluorescent protein (GFP) expression in the retina has been
achieved in an expanding repertoire of transgenic mouse lines, which are valuable tools for …

Refractive errors in vision can be caused by aberrant axial length of the eye, irregular
corneal shape, or lens abnormalities. Causes of eye length overgrowth include multiple …

Retinal diseases such as age-related macular degeneration (AMD), retinopathy of
prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual …

Upon arriving at their targets, developing axons cease pathfinding and begin instead to
arborize and form synapses. To test whether CNS arborization and synaptogenesis are …